Why Roebling

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Biomanufacturing

Scale-up economics and facility definition for biomass and precision fermentation, cell culture, and enzymatic production routes.

The business case in biomanufacturing rests on the price at which you can produce, and that price is decided at scale-up: where titer, yield, and recovery set COGS. Yet the model those numbers live in is usually a spreadsheet only one person can read, or a simulator run that is stale the week after it is delivered.

Our team will deliver a Roebling model that stays live from pilot to commercial. Feed it your pilot data and it returns a sized and priced facility, with unit economics you can put in front of a board or an investor, in days, not months.

Crystal bleecher, pe

biomanufacturing team lead

“Biomanufacturing is where chemical engineering meets biology, and biology always wins the negotiation. Sterile design, batch scheduling, mass and heat transfer optimization... every project is a puzzle where the smallest shortcut gets punished. That complexity is exactly why I love it.”

Previously

A new basis for scale-up economics

Sterile and hygienic design: years of firsthand experience specifying and validating systems for sterile fermentation and hygienic downstream processing.

Equipment design and specification: from batch scheduling's impact on equipment sizing, to fermentor mass and heat transfer optimization, to CIP system design.

GMP facility design: layouts built around people, material, and goods flow, not just process footprint. Finish requirements based on hygienic zoning plans.

One Partner, from R&D to FID

R&D

FID

Bench (TEA)

Is there a business case, and what must titer and yield reach?

AACE Class 5

For teams working from bench data.

Model the commercial facility early; set the titer, yield, and recovery targets the business case requires.

Bench (TEA)

Is there a business case, and what must titer and yield reach?

AACE Class 5

For teams working from bench data.

Model the commercial facility early; set the titer, yield, and recovery targets the business case requires.

Pilot (Scale-up)

Does the process hold at scale, and at what COGS?

AACE Class 4

For teams scaling from pilot to commercial.

The model refines as pilot data arrives; unit economics prepared for investor and board diligence.

Pilot (Scale-up)

Does the process hold at scale, and at what COGS?

AACE Class 4

For teams scaling from pilot to commercial.

The model refines as pilot data arrives; unit economics prepared for investor and board diligence.

Pilot (Scale-up)

Does the process hold at scale, and at what COGS?

AACE Class 4

For teams scaling from pilot to commercial.

The model refines as pilot data arrives; unit economics prepared for investor and board diligence.

Commercial (Facility Definition)

What do we build, and what will it actually cost?

AACE Class 3

For teams heading into FID.

One facility, sized and priced on the basis carried from the bench, alongside the detailed engineering the stage demands.

Commercial (Facility Definition)

What do we build, and what will it actually cost?

AACE Class 3

For teams heading into FID.

One facility, sized and priced on the basis carried from the bench, alongside the detailed engineering the stage demands.

Commercial (Facility Definition)

What do we build, and what will it actually cost?

AACE Class 3

For teams heading into FID.

One facility, sized and priced on the basis carried from the bench, alongside the detailed engineering the stage demands.

Get Started

Typical deliverables

Scoped to the decision at hand. Any of:

Technical definition

Basis of Design
Mass and energy balance
Fermentation and downstream equipment list
Batch schedules and equipment utilization tables
Utility and CIP loads
PFDs
P&IDs and equipment datasheets

Cost and economics

Techno-economic model with COGS in $/kg or $/g
Capital and operating cost ranges that tighten with the stage of study
Single-use against stainless comparison
Site comparison cases
CMO and CDMO quote benchmarks

What customers say about Roebling

“We wouldn't have raised our money without that. So, thank you.”

CEO

next-generation biomaterials company

“We wouldn't have raised our money without that. So, thank you.”

CEO

next-generation biomaterials company

“How quickly you got to the same number we did was amazing. Honestly, absolutely amazing. It gives me more confidence quoting customers than I have today.”

Senior Executive

NASDAQ biotech company

“How quickly you got to the same number we did was amazing. Honestly, absolutely amazing. It gives me more confidence quoting customers than I have today.”

Senior Executive

NASDAQ biotech company

“You can play through hundreds of different variants and then just choose the optimum one.”

Engineering Lead

global bioscience company

“You can play through hundreds of different variants and then just choose the optimum one.”

Engineering Lead

global bioscience company

“This would have taken me six months.”

Director of Fermentation

biotech manufacturer

“This would have taken me six months.”

Director of Fermentation

biotech manufacturer

Frequently Asked Questions about Roebling

How is this different from SuperPro?

A SuperPro run is static: resize one piece of equipment and the change is yours to propagate, unit by unit, by hand. Roebling's model is live, so a process change reprices the plant. And its cost basis is drawn from the plant you are actually building rather than inherited from another industry, with the source behind every number open to inspection.

How is this different from SuperPro?

Our pilot runs at 300 litres. How can you know what happens at 50,000?

Because the model works from the engineering, not the trend line. Mixing, mass and heat transfer, and the downstream train are sized from first principles at the target scale, with your titer, yield, and recovery as the inputs. Where scale introduces uncertainty, the model carries it as a stated range rather than a hidden assumption, and the range tightens as pilot data arrives. Every number stays traceable, so your team interrogates the basis instead of trusting a black box.

Our pilot runs at 300 litres. How can you know what happens at 50,000?